A Reference Range for Endogenous Gamma-Hydroxybutyrate in Urine by Gas Chromatography-Mass Spectrometry

Stability of plasma gamma-hydroxybutyrate determined by gas chromatography-positive ion chemical ionization-mass spectrometry.

An effective method for the determination of gamma-hydroxybutyric acid (GHB) in human plasma is described that utilizes a simple liquid-liquid extraction procedure and gas chromatography-positive ion chemical ionization-mass spectrometry (GC-PCI-MS). The method has been used to study the stability of plasma GHB under several storage conditions. Following the extraction with acetonitrile, GHB an...

Determination of levamisole in urine by gas chromatography-mass spectrometry.

The United States Public Health Service Substance Abuse and Mental Health Services Administration is alerting medical professionals that a substantial percentage of cocaine imported into the United States is adulterated with levamisole, a veterinary pharmaceutical that can cause blood cell disorders such as severe neutropenia and agranulocytosis. Levamisole HCl is the active ingredient in a num...

Gas Chromatography - Mass Spectrometry

Gas Chromatography-Mass Spectrometry

Gas chromatography (GC) is a widely applied technique in many branches of science and technology. For over half a century, GC has played a fundamental role in determining how many components and in what proportion they exist in a mixture. However, the ability to establish the nature and chemical structure of these separated and quantified compounds is ambiguous and reduced, and requires a spect...

Gas Chromatography - Mass Spectrometry